Targeted alpha therapy using short-lived alpha-particles and the promise of nanobodies as targeting vehicle

Targeted alpha therapy using short-lived alpha-particles and the promise of nanobodies as targeting vehicle

INTRODUCTION The combination of a targeted biomolecule that specifically defines the target and a radionuclide that delivers a cytotoxic payload offers a specific way to destroy cancer cells. Targeted radionuclide therapy (TRNT) aims to deliver cytotoxic radiation to cancer cells and causes minimal toxicity to surrounding healthy tissues. Recent advances using α-particle radiation emphasizes th...

synthesis of amido alkylnaphthols using nano-magnetic particles and surfactants

we used dbsa and nano-magnetic for the synthesis of amido alkylnaphtols.

Therapy of Ovarian Carcinoma by Targeted Delivery of Alpha-Particles Using Immunoliposomes Capable of Retaining Alpha-Emitting Daughters

Exposure of school children to alpha particles

Background: A substantial part of the public’s natural radiation dose is due to the inhalation of radon gas. Most of the exposure occurs indoors where the airborne concentration of radon and its decay products is usually higher than outdoors. Materials and Methods: Radon activity concentration has been measured twice in 50 classrooms in 5 levels (10 each) during summer and winter using solid-st...

Systemic Targeted Alpha Radiotherapy for Cancer

Background: The fundamental principles of internal targeted alpha therapy for cancer were established many decades ago.The high linear energy transfer (LET) of alpha radiation to the targeted cancer cellscauses double strand breaks in DNA. At the same time, the short range radiation spares adjacent normal tissues. This targeted approach complements conventional external beam radiotherapy and ch...